A couple of years ago I strained the muscles in my right forearm & exacerbated the injury regularly cycling to keep fit. Operating my computer mouse with my right hand continued to irritate my forearm & wrist. Out of necessity I decided to try using my mouse with my left hand.
It took a few days to get used to, & maybe a couple of weeks to feel completely comfortable. Now I actually prefer operating the mouse with my left hand. To be more specific, I use an conventional optical mouse with my left hand & a gesture mouse (something like an iPad) with my right. I can operate a mouse with either hand if I’m drinking a cup of coffee, talking on the telephone or writing a note. I find that it’s faster, more convenient, & less likely to repetitively strain the small muscles & tendons in my forearm.
It does take a little time & effort to retrain yourself, but the long-term benefits are well worth it.